{"id":4211,"date":"2021-01-11T14:34:53","date_gmt":"2021-01-11T13:34:53","guid":{"rendered":"https:\/\/www.grandazootecnici.it\/project\/transizione-4-0\/"},"modified":"2022-04-26T12:32:39","modified_gmt":"2022-04-26T10:32:39","slug":"transition-4-0","status":"publish","type":"project","link":"https:\/\/www.grandazootecnici.it\/en\/project\/transition-4-0\/","title":{"rendered":"Transition 4.0"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; custom_padding_last_edited=&#8221;off|desktop&#8221; _builder_version=&#8221;4.7.7&#8243; _module_preset=&#8221;default&#8221; background_image=&#8221;https:\/\/www.grandazootecnici.it\/wp-content\/uploads\/2021\/04\/img-tablet_versione-vecchia.jpg&#8221; max_width=&#8221;100%&#8221; min_height=&#8221;253px&#8221; custom_margin=&#8221;||||false|false&#8221; custom_padding=&#8221;||||false|false&#8221; custom_padding_phone=&#8221;15vh||15vh||true|false&#8221; bottom_divider_height=&#8221;40px&#8221;][et_pb_row _builder_version=&#8221;4.7.7&#8243; _module_preset=&#8221;default&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.7.7&#8243; _module_preset=&#8221;default&#8221;][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;4.7.7&#8243; _module_preset=&#8221;default&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.7.7&#8243; _module_preset=&#8221;default&#8221;][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.7.7&#8243; custom_padding=&#8221;||0px|||&#8221;][et_pb_row column_structure=&#8221;1_2,1_2&#8243; _builder_version=&#8221;4.7.7&#8243; _module_preset=&#8221;default&#8221; use_background_color_gradient=&#8221;on&#8221; background_color_gradient_start=&#8221;#FFC543&#8243; background_color_gradient_end=&#8221;rgba(0,0,0,0)&#8221; background_color_gradient_direction=&#8221;52deg&#8221; background_color_gradient_start_position=&#8221;70%&#8221; background_image=&#8221;https:\/\/www.grandazootecnici.it\/wp-content\/uploads\/2021\/05\/stalla_01_MOD.jpg&#8221; background_position=&#8221;center_left&#8221; background_blend=&#8221;overlay&#8221; width=&#8221;100%&#8221; custom_margin=&#8221;0px||||false|false&#8221; custom_padding=&#8221;60px|60px|60px|60px|true|false&#8221;][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.7.7&#8243; _module_preset=&#8221;default&#8221;][et_pb_text _builder_version=&#8221;4.7.7&#8243; _module_preset=&#8221;default&#8221; header_2_text_color=&#8221;#000000&#8243;]<\/p>\n<h2><strong>INNOVATIVE TRANSITION PROTOCOL 4.0<\/strong><\/h2>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.7.7&#8243; _module_preset=&#8221;default&#8221; text_text_color=&#8221;#000000&#8243; text_font_size=&#8221;14px&#8221; text_line_height=&#8221;18px&#8221;]<\/p>\n<p><strong>Transition 4.0<\/strong> was originally conceived as a <strong>working<\/strong> <strong>protocol<\/strong> aimed at introducing innovative analytical <strong>elements<\/strong> and \u00a0<strong>solutions<\/strong> applicable to the transition period<strong>.<\/strong><\/p>\n<p style=\"text-align: justify;\">It is commonly accepted that the &#8220;pillars&#8221; of peripartum bovine health have been consolidated for some decades now, which means that technical research <strong>should be devoted to what still remains partly unknown:<\/strong><\/p>\n<ul>\n<li><strong>The occurrence of milk hypoproduction at week 4 for a considerable percentage of cows<\/strong><\/li>\n<li><strong>High incidence of &#8220;orphan diseases&#8221; in the immediate postpartum phase<\/strong><\/li>\n<\/ul>\n<p><span>\u00a0<\/span><\/p>\n<p><span><\/span><\/p>\n<p><span><\/span><\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.7.7&#8243; _module_preset=&#8221;default&#8221;][et_pb_image src=&#8221;https:\/\/www.grandazootecnici.it\/wp-content\/uploads\/2021\/12\/Tranzizione-4.0_mod.png&#8221; title_text=&#8221;Tranzizione 4.0_mod&#8221; _builder_version=&#8221;4.7.7&#8243; _module_preset=&#8221;default&#8221;][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;3.25&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.7.7&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221;]<\/p>\n<div data-pm-slice=\"1 1 []\" data-en-clipboard=\"true\" style=\"text-align: justify;\"><strong>Transition 4.0\u00ae<\/strong> is a <strong>project <\/strong>exclusively conceived for dairy <strong>farmers<\/strong> by <strong>Granda Team<\/strong>; a dedicated support service which benefits from <strong>Granda Team\u2019s pluri-annual experience in the area of client service. It unites specialist skills and innovative nutritional products with scientific testing supported by NUTRIL. HUB.<\/strong><\/div>\n<div data-pm-slice=\"1 1 []\" data-en-clipboard=\"true\" style=\"text-align: justify;\"><\/div>\n<div data-pm-slice=\"1 1 []\" data-en-clipboard=\"true\" style=\"text-align: justify;\">\n<p><strong>NUTRIL.HUB is an operational tool<\/strong> created by <strong>GRANDA TEAM<\/strong> that transmits and analyzes technical data and metabolic readings to provide<strong> a 360\u00b0 analysis on the incidence of peripartum pathologies<\/strong> and the <strong>negative consequences they induce in the lactation phase.<\/strong> With a particular focus on technical ideas made available by innovative and &#8220;cutting edge&#8221; research, <strong>products can be constantly reformulated to be more performant and technically up to date. <\/strong><\/p>\n<\/div>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;4.7.7&#8243; _module_preset=&#8221;default&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.7.7&#8243; _module_preset=&#8221;default&#8221;][et_pb_text _builder_version=&#8221;4.7.7&#8243; _module_preset=&#8221;default&#8221;]<\/p>\n<h2>GRANDA \u00a0TEAM&#8217;S TRANSITION 4.0 PROTOCOL <span style=\"color: #333333;\">FOCUSES ON THE FOLLOWING MACRO-TOPICS:<\/span><\/h2>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;4.7.7&#8243; _module_preset=&#8221;default&#8221; width=&#8221;97%&#8221; custom_margin=&#8221;||0px||false|false&#8221; custom_padding=&#8221;||0px||false|false&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.7.7&#8243; _module_preset=&#8221;default&#8221;][et_pb_accordion open_toggle_text_color=&#8221;#242424&#8243; closed_toggle_text_color=&#8221;#ffffff&#8221; _builder_version=&#8221;4.7.7&#8243; _module_preset=&#8221;default&#8221; min_height=&#8221;615.1px&#8221; hover_enabled=&#8221;0&#8243; sticky_enabled=&#8221;0&#8243;][et_pb_accordion_item title=&#8221;NMA: GRANDA TEAM&#8217;S ANSWER TO THE ISSUE OF KETOSIS&#8221; open=&#8221;on&#8221; open_toggle_text_color=&#8221;#242424&#8243; open_toggle_background_color=&#8221;rgba(0,0,0,0)&#8221; closed_toggle_background_color=&#8221;#FFC543&#8243; use_icon_font_size=&#8221;on&#8221; _builder_version=&#8221;4.7.7&#8243; _module_preset=&#8221;default&#8221; hover_enabled=&#8221;0&#8243; toggle_text_color=&#8221;#242424&#8243; sticky_enabled=&#8221;0&#8243;]<\/p>\n<p><strong><img loading=\"lazy\" src=\"https:\/\/www.grandazootecnici.it\/wp-content\/uploads\/2021\/06\/iStock-187483188_unrestricted_2000x600-300x90.jpg\" width=\"554\" height=\"178\" alt=\"\" class=\"wp-image-1227 alignnone size-medium\" style=\"display: block; margin-left: auto; margin-right: auto;\" \/><\/strong><\/p>\n<p style=\"text-align: justify;\"><strong>The nature of genetic selection in reproduction already <\/strong>inflicts <strong>a quasi-constant and persistent degree of<\/strong> <strong>lipid mobilization <\/strong>in <strong>the peripartum phase; <\/strong>\u00a0therefore it is not possible to classify \u00a0lipid mobilization as a <strong>veritable<\/strong> <strong>pathology, but rather a human induced metabolic necessity that we have to get used to managing.<\/strong><\/p>\n<h3 style=\"text-align: center;\">WHAT IS THE CORRECT APPROACH to managing LIPID MOBILIZATION IN the TRANSITION period?<\/h3>\n<p style=\"text-align: justify;\"><strong><br \/> <\/strong>It is the adoption of an innovative and complete diagnostic-nutritional approach whose objective is to provide assistance to herds during the peripartum phase. This involves managing the flow of fats subject to mobilization and their subsequent metabolization allowing us to immediately ascertain exact levels of fats and how they will be metabolized. Even though NEFA and ketones are not strictly associated in diagnostic terms, they both synergistically target the same organ (hepatic cells in the liver). It is therefore necessary to stimulate and increase lipid mobilization and the oxidation of fats in the liver without neglecting nor underestimating the importance of each cofactor present in this metabolic pathway.<\/p>\n<h3 style=\"text-align: center;\">THE TRANSITION RESPONSE 4.0 (NMA NEB MANAGEMENT APPROACH OF GRANDA TEAM)<\/h3>\n<p style=\"text-align: justify;\"><strong>&#8220;Epat-ox<\/strong> <strong>\u00a0transition&#8221; is <\/strong>a specific solution that represents <strong>a new approach to herds in Transition.<\/strong> This solution, researched and produced by Granda Team, can be applied to <strong>cows affected<\/strong> <strong>by <\/strong><strong>NEB <\/strong>presenting high serum values of\u00a0 <strong>NEFA and BHBA.<\/strong> For use during the <strong>peripartum period, <\/strong>this product<strong> simultaneously achieves excellent production performance with an extremely low incidence of metabolic disease.<\/strong><\/p>\n<p style=\"text-align: justify;\"><strong><\/strong><\/p>\n<p style=\"text-align: center;\">\u00a0<a href=\"https:\/\/www.grandazootecnici.it\/en\/project\/epatox-transition\/\" title=\"epatox\"><img loading=\"lazy\" src=\"https:\/\/www.grandazootecnici.it\/wp-content\/uploads\/2021\/06\/Epat-ox-transition_-1-300x153.png\" width=\"418\" height=\"213\" alt=\"\" class=\"wp-image-1229 alignnone size-medium\" \/><\/a><\/p>\n<p>[\/et_pb_accordion_item][et_pb_accordion_item title=&#8221;CONTROLLING HYPOCALCEMIA IS NO LONGER PROBLEMATIC &#8221; open_toggle_text_color=&#8221;#242424&#8243; open_toggle_background_color=&#8221;rgba(0,0,0,0)&#8221; closed_toggle_background_color=&#8221;#FFC543&#8243; use_icon_font_size=&#8221;on&#8221; _builder_version=&#8221;4.7.7&#8243; _module_preset=&#8221;default&#8221; hover_enabled=&#8221;0&#8243; toggle_text_color=&#8221;#242424&#8243; open=&#8221;off&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<p><img loading=\"lazy\" src=\"https:\/\/www.grandazootecnici.it\/wp-content\/uploads\/2021\/06\/bWFpbi9BUlRJQ09MSS9mb3RvLWJsb2ctMjktMTQtMTU5ODUxOTgzOC5qcGc-1-300x125.jpg\" width=\"500\" height=\"208\" alt=\"\" class=\"wp-image-1240 alignnone size-medium\" style=\"display: block; margin-left: auto; margin-right: auto;\" \/><\/p>\n<p style=\"text-align: justify;\">While acknowledging <strong>the importance of reducing the nutritional intake of potassium (K+)<\/strong> \u00a0(Goff \u00a0et al. 2004), it is nonetheless necessary to have a solution at hand that can be <strong>used whenever an excess intake of K+ is NOT solely manageable through fodder choice.<\/strong><\/p>\n<p style=\"text-align: justify;\"><strong>When managing<\/strong><strong> the TRANSITION phase,<\/strong> <strong>nutritionists\u2019 aim<\/strong><strong> to restrict potassium intake during the close<\/strong> <strong>up stage<\/strong><strong>.<\/strong> It is clear however, to all those managing dairy cowsheds, that the most suitable fodder choice to achieve this objective poses serious problems.<\/p>\n<p style=\"text-align: justify;\">In order to correctly calculate DCAD as a ratio, it is necessary to know the total amount of K+ ingested by cows, and unfortunately the specialized software is unable to calculate it directly due to widely fluctuating levels of calcium present in fodder that are considered poor in K+ (e.g. corn silage\u00a0 or straw). These types of fodder are often included in the ratio with the aim of reducing the overall intake administered.<\/p>\n<h3 style=\"text-align: center;\">WHAT IS THE CORRECT APPROACH TO RESTRICTING POTASSIUM INTAKE DURING THE CLOSE UP PHASE AND REDUCING HYPOCALCEMIA?<\/h3>\n<ul>\n<li>Not relying on potassium values emanating from traditional bibliographical sources<\/li>\n<li>Choosing the easiest to analyze substrate<\/li>\n<li>Selecting the most accurate method<\/li>\n<li>Cross-validating software data with that provided by urinary analyses<\/li>\n<\/ul>\n<h3 style=\"text-align: center;\">GRANDA TEAM&#8217;S RESPONSE USING THE TRANSITION 4.0 PROTOCOL<\/h3>\n<h5><strong>CAPTURING EXCESS POTASSIUM<\/strong><\/h5>\n<p style=\"text-align: justify;\">K+ (as well as calcium) can be captured by supplying and administering the correct dosage of aluminosilicates.<br \/> To do this, you need a biological substrate indicator that can determine total potassium ingested and precisely determine much K+ needs to be captured; note that for this purpose the hematic value is irrelevant given that large quantities of minerals are excreted through the urine in order to maintain the narrow value ranges of homeostasis.<\/p>\n<p><strong>Granda<\/strong>\u00a0<strong>Team&#8217;s CATION REM<\/strong>\u00a0 solution <strong>is able to render a portion of potassium non-absorbable.<\/strong><\/p>\n<p style=\"text-align: justify;\"><strong>In fact, testing has established that CATION REM, when inserted into CLOSE UP rations, 15 days prior to calving, allows potassium absorption levels equal to 50% of total intake present in the ration.<\/strong><\/p>\n<p style=\"text-align: justify;\"><strong><\/strong><\/p>\n<p style=\"text-align: center;\"><a href=\"https:\/\/www.grandazootecnici.it\/en\/project\/cation-rem\/\" title=\"CATION REM\"><b><img loading=\"lazy\" src=\"https:\/\/www.grandazootecnici.it\/wp-content\/uploads\/2021\/06\/CATION-REM_mod-300x191.png\" width=\"300\" height=\"191\" alt=\"\" class=\"wp-image-1245 alignnone size-medium\" \/><\/b><\/a><\/p>\n<h5><\/h5>\n<h5><strong>ANIONIC STRATEGY<\/strong><\/h5>\n<p>A balanced and protracted anion strategy using the <strong>DCADD solution<\/strong> which has both a neutral effect on palatability of the final product and doesn\u2019t interfere with the ingestion capacity of Dry Matter.<\/p>\n<p style=\"text-align: center;\"><a href=\"https:\/\/www.grandazootecnici.it\/en\/project\/dcadd\/\" title=\"DCADD\"><strong><img loading=\"lazy\" src=\"https:\/\/www.grandazootecnici.it\/wp-content\/uploads\/2021\/10\/DCADD-technical-sheet-300x238.jpg\" width=\"300\" height=\"238\" alt=\"\" class=\"wp-image-2331 alignnone size-medium\" \/><\/strong><\/a><\/p>\n<p>[\/et_pb_accordion_item][et_pb_accordion_item title=&#8221;RUMEN HEALTH: Is the cow still a ruminant? &#8230;.. For us YES!!!&#8221; open_toggle_text_color=&#8221;#242424&#8243; open_toggle_background_color=&#8221;rgba(0,0,0,0)&#8221; closed_toggle_background_color=&#8221;#FFC543&#8243; use_icon_font_size=&#8221;on&#8221; _builder_version=&#8221;4.7.7&#8243; _module_preset=&#8221;default&#8221; hover_enabled=&#8221;0&#8243; toggle_text_color=&#8221;#242424&#8243; open=&#8221;off&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<p style=\"text-align: center;\"><img loading=\"lazy\" src=\"https:\/\/www.grandazootecnici.it\/wp-content\/uploads\/2021\/05\/alimentazione-delle-vacche-300x158.jpg\" width=\"442\" height=\"242\" alt=\"\" class=\"wp-image-1114 alignnone size-medium\" \/><\/p>\n<p style=\"text-align: justify;\"><strong>Rumen health<\/strong> is crucial for dairy cattle. Finding the right balance of this\u00a0<strong>varied &#8220;condominium&#8221;<\/strong>\u00a0<strong>should never be far from sight <\/strong>in terms of efficiency and more importantly intrinsic pathogenicity.<\/p>\n<p style=\"text-align: justify;\">It is therefore very important to dedicate attention to how rumen adapt to lactation ration by taking advantage of information emanating from various studies on this aspect which highlight the importance of avoiding sudden variations in dry, close-up and postpartum diet.<\/p>\n<p style=\"text-align: justify;\"><strong>Therefore, the close-up<\/strong> <strong>formulation ration needs to follow specific prescriptions and targeted concentrations of energy, protein and minerals.<\/strong>\u00a0Unfortunately, this is not always possible and non-compliance of this necessity is responsible for considerable problems.<\/p>\n<p style=\"text-align: justify;\">The reasons as to why incorrect and unsuitable dietary rations are often administered can be manifold ranging from company size, absence of a prepartum group, lack of staff and even owners\u2019 inattentiveness. The subsequent effect is the emergence of pathological <strong>conditions in the postpartum period<\/strong>; such conditions can reduce<strong> production levels and reproductive performance.<\/strong><\/p>\n<h3 style=\"text-align: center;\"><strong>GRANDA TEAM&#8217;S RESPONSE WITH THE TRANSITION 4.0 PROTOCOL<\/strong><\/h3>\n<p style=\"text-align: justify;\">It is fundamental to pay particular attention to <strong>LPS (Lipopolysaccharide Membranes) <\/strong>which are classed as metabolites at the top of xenobiotic toxicity chart (micrograms\/ml) and produce proteins in the acute phase that then go on to provoke both acute and chronic effects.<\/p>\n<p style=\"text-align: justify;\"><strong>It is therefore crucial to reduce the negative effects of LPS and prevent them from entering the circulatory system; this is important regardless of the prepartum management style adopted and the inevitable variations naturally taking place in a\u00a0ruminal ecosystem\u00a0during this phase.\u00a0<\/strong><strong>The TOX REM solution is the perfect product as it contains specific LPS deactivators that can achieve this objective. <\/strong><\/p>\n<p style=\"text-align: justify;\">In fact,<strong> TOX REM\u2019s <\/strong>action works independently of circulating endotoxin levels making it effective even when concentration levels are high.<\/p>\n<p style=\"text-align: justify;\"><strong>Granda<\/strong> <strong>Team&#8217;s TOX REM<\/strong> <strong>solution effectively <\/strong>achieves<strong> LPS inactivation at both local and systemic levels, thereby averting the harmful consequences of systemic inflammation (vasodilatation, fever, peripheral shock, loss <\/strong><strong>of appetite).<\/strong> In addition, there is also <strong>the risk <\/strong><strong>of impaired normal <\/strong><strong>pre-stomach activity<\/strong> <strong>that is already put to the test in the postpartum period as a result of significant variations occurring in the ration.<\/strong><\/p>\n<p style=\"text-align: center;\"><a href=\"https:\/\/www.grandazootecnici.it\/en\/project\/tox-rem\/\" title=\"TOX REM\"><strong><img loading=\"lazy\" src=\"https:\/\/www.grandazootecnici.it\/wp-content\/uploads\/2021\/06\/TOX-REM_mod-300x194.png\" width=\"329\" height=\"213\" alt=\"\" class=\"wp-image-1256 alignnone size-medium\" \/><\/strong><\/a><\/p>\n<p>[\/et_pb_accordion_item][et_pb_accordion_item title=&#8221;More progesterone&#8230;.less inflammation&#8230;.please!!&#8221; open_toggle_text_color=&#8221;#242424&#8243; open_toggle_background_color=&#8221;rgba(0,0,0,0)&#8221; closed_toggle_background_color=&#8221;#FFC543&#8243; use_icon_font_size=&#8221;on&#8221; _builder_version=&#8221;4.7.7&#8243; _module_preset=&#8221;default&#8221; hover_enabled=&#8221;0&#8243; toggle_text_color=&#8221;#242424&#8243; open=&#8221;off&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<p style=\"text-align: center;\"><img loading=\"lazy\" src=\"https:\/\/www.grandazootecnici.it\/wp-content\/uploads\/2021\/10\/vitello34243-300x169.jpg\" width=\"470\" height=\"265\" alt=\"\" class=\"wp-image-2017 alignnone size-medium\" \/><\/p>\n<p>In recent years scientific knowledge surrounding <strong>cattle<\/strong> <strong>hypo fertility issues \u00a0<\/strong>have experienced a radical about turn.<\/p>\n<p>Through studying cows\u2019 ovarian cycles, it has been proven that the development of a fertile follicle is dependent on two metabolically related factors:<\/p>\n<p style=\"text-align: justify;\">&#8211;<strong>the concentration of progesterone in the blood<\/strong><\/p>\n<p style=\"text-align: justify;\">&#8211;<strong>reducing systemic inflammation present in the postpartum phase, especially in summer (also known as &#8220;heat<\/strong> <strong>\u00a0stress&#8221;).<\/strong><\/p>\n<p style=\"text-align: justify;\">The concentration <strong>of the fertility hormone (progesterone) <\/strong>and\u00a0<strong>the quantification of inflammatory stress <\/strong>are, therefore, the two key factors to be analyzed in the fight <strong>against bovine hypo fertility,<\/strong> especially in the presence of <strong>&#8220;stressogenic&#8221; <\/strong><strong>factors <\/strong>that negatively impact the formation of a new pregnancy (heat stress, mycotoxins, etc..<\/p>\n<h3 style=\"text-align: center;\">MORE PROGESTERONE&#8230; YES PLEASE!!<\/h3>\n<p style=\"text-align: justify;\"><em>&#8220;Progesterone is essential to a normal reproductive cycle because it inhibits estrous and controls follicle growth. However, some high-yielding dairy cows have important circulatory progesterone deficiencies.&#8221;<\/em><\/p>\n<p><em><b>Penn State University<\/b><\/em><\/p>\n<p><em>&#8220;Circulating P4 concentrations represent the balance between P4 production and P4 metabolism; P4 metabolism is principally related to the quantity of blood flow to the liver due to an excess of enzymes that mediate P4 metabolism.&#8221;<\/em><\/p>\n<p><b><i>M.C.Wiltbank<\/i><\/b><b><i>, <\/i><\/b><b><i>A.H.Souza<\/i><\/b><b><i>, P.D. Carvalho, <\/i><\/b><b><i>A.P.Cunha<\/i><\/b><b><i>, <\/i><\/b><b><i>J.O.Giordano<\/i><\/b><b><i>, <\/i><\/b><b><i>P.M.Fricke<\/i><\/b><b><i>, <\/i><\/b><b><i>G.M.Baez<\/i><\/b><b><i> and M.G. <\/i><\/b><b><i>Diskin<\/i><\/b><b><i>,\u00a0 2014<\/i><\/b><\/p>\n<p><b><i><\/i><\/b><\/p>\n<h3 style=\"text-align: center;\">LESS INFLAMMATION&#8230; YES PLEASE!!<\/h3>\n<p><strong>INFLAMMATION and FERTILITY: a difficult relationship<\/strong>\u00a0<\/p>\n<ul>\n<li>Reduced production of FSH and LH hormones (less follicular development and absence of ovulation)<\/li>\n<li>Luteolytic action of prostaglandins: reduced blood progesterone levels and embryonic mortality<\/li>\n<li>Uterine action: glandular epithelium reduction: &gt; embryonic reabsorption<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" src=\"https:\/\/www.grandazootecnici.it\/wp-content\/uploads\/2021\/10\/Immagine1-300x137.jpg\" width=\"488\" height=\"223\" alt=\"\" class=\"wp-image-2019 alignnone size-medium\" style=\"display: block; margin-left: auto; margin-right: auto;\" srcset=\"https:\/\/www.grandazootecnici.it\/wp-content\/uploads\/2021\/10\/Immagine1-300x137.jpg 300w, https:\/\/www.grandazootecnici.it\/wp-content\/uploads\/2021\/10\/Immagine1.jpg 433w\" sizes=\"(max-width: 488px) 100vw, 488px\" \/><\/p>\n<p style=\"text-align: center;\"><em>Correlation between Hp in peripartum and subsequent ovulation<\/em><\/p>\n<p style=\"text-align: center;\"><em><\/em><\/p>\n<p style=\"text-align: center;\"><b><img loading=\"lazy\" src=\"https:\/\/www.grandazootecnici.it\/wp-content\/uploads\/2021\/10\/vaccavitello-iStock-300x169.jpg\" width=\"567\" height=\"319\" alt=\"\" class=\"wp-image-2020 alignnone size-medium\" srcset=\"https:\/\/www.grandazootecnici.it\/wp-content\/uploads\/2021\/10\/vaccavitello-iStock-300x169.jpg 567w, https:\/\/www.grandazootecnici.it\/wp-content\/uploads\/2021\/10\/vaccavitello-iStock-480x270.jpg 480w\" sizes=\"(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) 567px, 100vw\" \/><\/b><\/p>\n<h3 style=\"text-align: center;\"><b><\/b>GRANDA TEAM ANSWER ON FERTILITY MANAGEMENT<\/h3>\n<p>[\/et_pb_accordion_item][\/et_pb_accordion][et_pb_button button_url=&#8221;https:\/\/www.grandazootecnici.it\/en\/project\/fertilitymanagement\/&#8221; button_text=&#8221;Fertility management \u2013 find out more&#8221; button_alignment=&#8221;center&#8221; _builder_version=&#8221;4.7.7&#8243; _module_preset=&#8221;default&#8221; hover_enabled=&#8221;0&#8243; sticky_enabled=&#8221;0&#8243;][\/et_pb_button][et_pb_text _builder_version=&#8221;4.7.7&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;||0px|||&#8221;]<\/p>\n<h2 class=\"tithome\"><span style=\"color: #000000;\">LET&#8217;S KEEP<\/span> <span style=\"color: #ffcc00;\">IN TOUCH<\/span><\/h2>\n<p class=\"tithome\"><span style=\"color: #000000;\">ask the Granda expert<\/span><\/p>\n<p>&nbsp;<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;Sezione&#8221; _builder_version=&#8221;4.7.7&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;#f1f1f1&#8243; animation_style=&#8221;fade&#8221; global_module=&#8221;5034&#8243; saved_tabs=&#8221;all&#8221;][et_pb_row column_structure=&#8221;1_4,1_4,1_4,1_4&#8243; _builder_version=&#8221;4.7.7&#8243; _module_preset=&#8221;default&#8221; width=&#8221;97%&#8221;][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;4.7.7&#8243; _module_preset=&#8221;default&#8221; animation_style=&#8221;slide&#8221; animation_direction=&#8221;bottom&#8221; animation_delay=&#8221;500ms&#8221;][et_pb_text _builder_version=&#8221;4.7.7&#8243; _module_preset=&#8221;default&#8221;]<div role=\"form\" class=\"wpcf7\" id=\"wpcf7-f4085-o1\" lang=\"en-US\" dir=\"ltr\">\n<div class=\"screen-reader-response\"><p role=\"status\" aria-live=\"polite\" aria-atomic=\"true\"><\/p> <ul><\/ul><\/div>\n<form action=\"\/en\/wp-json\/wp\/v2\/project\/4211#wpcf7-f4085-o1\" method=\"post\" class=\"wpcf7-form init\" novalidate=\"novalidate\" data-status=\"init\">\n<div style=\"display: none;\">\n<input type=\"hidden\" name=\"_wpcf7\" value=\"4085\" \/>\n<input type=\"hidden\" name=\"_wpcf7_version\" value=\"5.5.3\" \/>\n<input type=\"hidden\" name=\"_wpcf7_locale\" value=\"en_US\" \/>\n<input type=\"hidden\" name=\"_wpcf7_unit_tag\" value=\"wpcf7-f4085-o1\" \/>\n<input type=\"hidden\" name=\"_wpcf7_container_post\" value=\"0\" \/>\n<input type=\"hidden\" name=\"_wpcf7_posted_data_hash\" value=\"\" \/>\n<input type=\"hidden\" name=\"_wpcf7_recaptcha_response\" value=\"\" \/>\n<\/div>\n<p><label><span class=\"wpcf7-form-control-wrap your-name\"><input type=\"text\" name=\"your-name\" value=\"\" size=\"40\" class=\"wpcf7-form-control wpcf7-text wpcf7-validates-as-required\" aria-required=\"true\" aria-invalid=\"false\" placeholder=\"Name ad Last Name*\" \/><\/span> <\/label><\/p>\n<p><label> <span class=\"wpcf7-form-control-wrap your-email\"><input type=\"email\" name=\"your-email\" value=\"\" size=\"40\" class=\"wpcf7-form-control wpcf7-text wpcf7-email wpcf7-validates-as-required wpcf7-validates-as-email\" aria-required=\"true\" aria-invalid=\"false\" placeholder=\"E-mail address*\" \/><\/span> <\/label><\/p>\n<p><label> <span class=\"wpcf7-form-control-wrap your-phone\"><input type=\"text\" name=\"your-phone\" value=\"\" size=\"40\" class=\"wpcf7-form-control wpcf7-text wpcf7-validates-as-required\" aria-required=\"true\" aria-invalid=\"false\" placeholder=\"Phone*\" \/><\/span> <\/label><\/p>\n<p><label> <span class=\"wpcf7-form-control-wrap your-message\"><textarea name=\"your-message\" cols=\"40\" rows=\"10\" class=\"wpcf7-form-control wpcf7-textarea\" aria-invalid=\"false\" placeholder=\"Messagge\"><\/textarea><\/span> <\/label><\/p>\n<p><span class=\"acceptate\"><span class=\"wpcf7-form-control-wrap acceptance-768\"><span class=\"wpcf7-form-control wpcf7-acceptance\"><span class=\"wpcf7-list-item\"><input type=\"checkbox\" name=\"acceptance-768\" value=\"1\" aria-invalid=\"false\" \/><\/span><\/span><\/span> *I authorize the processing of data<\/span><\/p>\n<p><input type=\"submit\" value=\"Submit\" class=\"wpcf7-form-control has-spinner wpcf7-submit\" \/><\/p>\n<div class=\"wpcf7-response-output\" aria-hidden=\"true\"><\/div><\/form><\/div>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;4.7.7&#8243; _module_preset=&#8221;default&#8221; animation_style=&#8221;slide&#8221; animation_direction=&#8221;bottom&#8221; animation_delay=&#8221;750ms&#8221;][et_pb_image src=&#8221;https:\/\/www.grandazootecnici.it\/wp-content\/uploads\/2021\/01\/mail.jpg&#8221; title_text=&#8221;mail&#8221; _builder_version=&#8221;4.7.7&#8243; _module_preset=&#8221;default&#8221;][\/et_pb_image][et_pb_text _builder_version=&#8221;4.7.7&#8243; _module_preset=&#8221;default&#8221; text_font_size=&#8221;12px&#8221;]<\/p>\n<h4 class=\"titcontatti\">Write to us<\/h4>\n<p><span style=\"color: #000000;\"><a href=\"customercare@grandazootecnici.it\" style=\"color: #000000;\">customercare@grandazootecnici.it<\/a><\/span><\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;4.7.7&#8243; _module_preset=&#8221;default&#8221; animation_style=&#8221;slide&#8221; animation_direction=&#8221;bottom&#8221; animation_delay=&#8221;750ms&#8221;][et_pb_image src=&#8221;https:\/\/www.grandazootecnici.it\/wp-content\/uploads\/2021\/01\/chiama.jpg&#8221; title_text=&#8221;chiama&#8221; _builder_version=&#8221;4.7.7&#8243; _module_preset=&#8221;default&#8221;][\/et_pb_image][et_pb_text _builder_version=&#8221;4.7.7&#8243; _module_preset=&#8221;default&#8221; text_font_size=&#8221;12px&#8221;]<\/p>\n<h4 class=\"titcontatti\">Call us<\/h4>\n<p><span style=\"color: #000000;\"><a href=\"tel:+390172712734\" style=\"color: #000000;\">+39 0172 712734<\/a><\/span><\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;4.7.7&#8243; _module_preset=&#8221;default&#8221; animation_style=&#8221;slide&#8221; animation_direction=&#8221;bottom&#8221; animation_delay=&#8221;750ms&#8221;][et_pb_image src=&#8221;https:\/\/www.grandazootecnici.it\/wp-content\/uploads\/2021\/01\/chat.jpg&#8221; title_text=&#8221;chat&#8221; _builder_version=&#8221;4.7.7&#8243; _module_preset=&#8221;default&#8221;][\/et_pb_image][et_pb_text _builder_version=&#8221;4.7.7&#8243; _module_preset=&#8221;default&#8221; text_font_size=&#8221;12px&#8221;]<\/p>\n<h4 class=\"titcontatti\">Where we are<\/h4>\n<p>Via P. Massia 1, 12038 Savigliano (CN)<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; custom_padding_last_edited=&#8221;off|desktop&#8221; _builder_version=&#8221;4.7.7&#8243; _module_preset=&#8221;default&#8221; background_image=&#8221;https:\/\/www.grandazootecnici.it\/wp-content\/uploads\/2021\/04\/img-tablet_versione-vecchia.jpg&#8221; max_width=&#8221;100%&#8221; min_height=&#8221;253px&#8221; custom_margin=&#8221;||||false|false&#8221; custom_padding=&#8221;||||false|false&#8221; custom_padding_phone=&#8221;15vh||15vh||true|false&#8221; bottom_divider_height=&#8221;40px&#8221;][et_pb_row _builder_version=&#8221;4.7.7&#8243; _module_preset=&#8221;default&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.7.7&#8243; _module_preset=&#8221;default&#8221;][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;4.7.7&#8243; _module_preset=&#8221;default&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.7.7&#8243; _module_preset=&#8221;default&#8221;][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.7.7&#8243; custom_padding=&#8221;||0px|||&#8221;][et_pb_row column_structure=&#8221;1_2,1_2&#8243; _builder_version=&#8221;4.7.7&#8243; _module_preset=&#8221;default&#8221; use_background_color_gradient=&#8221;on&#8221; background_color_gradient_start=&#8221;#FFC543&#8243; background_color_gradient_end=&#8221;rgba(0,0,0,0)&#8221; background_color_gradient_direction=&#8221;52deg&#8221; background_color_gradient_start_position=&#8221;70%&#8221; background_image=&#8221;https:\/\/www.grandazootecnici.it\/wp-content\/uploads\/2021\/05\/stalla_01_MOD.jpg&#8221; background_position=&#8221;center_left&#8221; background_blend=&#8221;overlay&#8221; width=&#8221;100%&#8221; custom_margin=&#8221;0px||||false|false&#8221; custom_padding=&#8221;60px|60px|60px|60px|true|false&#8221;][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.7.7&#8243; _module_preset=&#8221;default&#8221;][et_pb_text _builder_version=&#8221;4.7.7&#8243; _module_preset=&#8221;default&#8221; header_2_text_color=&#8221;#000000&#8243;] INNOVATIVE TRANSITION PROTOCOL 4.0 [\/et_pb_text][et_pb_text _builder_version=&#8221;4.7.7&#8243; _module_preset=&#8221;default&#8221; text_text_color=&#8221;#000000&#8243; text_font_size=&#8221;14px&#8221; text_line_height=&#8221;18px&#8221;] [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":3600,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"<p>Transizione 4.0\u00ae \u00e8 un progetto esclusivo ideato da Granda Team rivolto agli allevatori produttori di latte che<br \/>si prefigge di massimizzare l\u2019ingestione di sostanza secca prima e dopo il parto, la produzione di latte alla<br \/>quarta settimana e di ridurre al minimo l\u2019incidenza di patologie grazie ad un servizio di supporto che nasce<br \/>dall\u2019esperienza pluriannuale del customer service Granda Team mettendo insieme competenze specifiche , prodotti<\/p><p>nutrizionali innovativi , testati scientificamente e tecnologia on farm \u2013diagnostica di campo.<\/p>","_et_gb_content_width":""},"project_category":[50],"project_tag":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.grandazootecnici.it\/en\/wp-json\/wp\/v2\/project\/4211"}],"collection":[{"href":"https:\/\/www.grandazootecnici.it\/en\/wp-json\/wp\/v2\/project"}],"about":[{"href":"https:\/\/www.grandazootecnici.it\/en\/wp-json\/wp\/v2\/types\/project"}],"author":[{"embeddable":true,"href":"https:\/\/www.grandazootecnici.it\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.grandazootecnici.it\/en\/wp-json\/wp\/v2\/comments?post=4211"}],"version-history":[{"count":13,"href":"https:\/\/www.grandazootecnici.it\/en\/wp-json\/wp\/v2\/project\/4211\/revisions"}],"predecessor-version":[{"id":5189,"href":"https:\/\/www.grandazootecnici.it\/en\/wp-json\/wp\/v2\/project\/4211\/revisions\/5189"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.grandazootecnici.it\/en\/wp-json\/wp\/v2\/media\/3600"}],"wp:attachment":[{"href":"https:\/\/www.grandazootecnici.it\/en\/wp-json\/wp\/v2\/media?parent=4211"}],"wp:term":[{"taxonomy":"project_category","embeddable":true,"href":"https:\/\/www.grandazootecnici.it\/en\/wp-json\/wp\/v2\/project_category?post=4211"},{"taxonomy":"project_tag","embeddable":true,"href":"https:\/\/www.grandazootecnici.it\/en\/wp-json\/wp\/v2\/project_tag?post=4211"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}