Objective:

Formulation of increasingly performing and technically up-to-date nutritional solutions

Total support to the farmer in terms of service to improve and maintain the cows health and welfare in the peripartum period and the results in lactation

1. NMA (Neb Management Approach): THE GRANDA TEAM’S ANSWER TO THE KETOSIS PROBLEM

“The genetic selection of the production character will impose an almost constant and persistent amount of lipomobilisation in the peripartum phase; therefore it’s not possible to consider lipomobilisation a real pathology but a metabolic necessity that we have induced and that we will have to get used to managing.”

WHAT IS THE CORRECT APPROACH TO THE LIPOMOBILIZATION MANAGEMENT IN THE TRANSITION PHASE?

An innovative and all-inclusive diagnostic and nutritional approach that aims to help the herd, during peipartum phase, to manage the flow and subsequent mobilized fats metabolization, by immediately knowing the mobilized lipids real entity and their metabolic destiny: in fact, it must not be forgotten that NEFA and KETONS, even if they are not correlated in the diagnostic terms, both have the same target organ (the liver cell) and in a synergistic way.  Therefore, lipomobilisation and the subsequent fats oxidation in the liver it must be stimulated and increased, without neglecting or underestimating the importance of each cofactor present in this metabolic pathway.

GRANDA TEAM’S RESPONSE WITH TRANSIZIONE 4.0 PROGRAM

An innovative approach to the herd during transition period with specific solution use, called “Epat-ox transition” (Solution developed and produced by Granda Team). This specific solution, applied to dairy cows affected by NEGATIVE ENERGY BALANCE and with high blood NEFA and BHBA values, allows to face up to the peripartum period while keeping the herd healthy and achieving excellent production performance as well as a very low metabolic diseases incidence.

2. CONTROLLING HYPOCALCEMIA IS NO LONGER PROBLEMATIC…

SINGLE DRYING GROUP (-60 DAYS BEFORE CALVING)

“NO Vitamin D3 ….. NO Ca2+ (ionized blood calcium)!!!”

“How much calcidiol is present in dairy cow in the prepartum phase?”

“Is it possible to increase the calcidiol level with vitamin D3 normally commercial sources?

GRANDA TEAM’S RESPONSE WITH TRANSIZIONE 4.0 PROGRAM

The DRY-CARE nutritional solution proposed by GRANDA TEAM is a new approach to the hypocalcemia management, specially formulated for all farms where there is a single DRY group (- 60 days from calving). Effective, simple and highly performing solution.

The hypocalcemia prevention, obtained with DRY CARE solution use, is based on the vitamin D3 correct reintegration/storage. This innovative solution also has a stimulating effect on the dairy cow immune function dring dry period and positive repercussions on uterus and breast health at the calving time.

The reintegration of the HYPOAVITAMINOSIS D3 real existence in dairy cow during the dry period takes the form of a new and innovative technology developed and formulated by Granda Team and included in the DRY CARE solution, trade name

with the aim of restoring the blood content of Vitamin D3 and its storage in the adipose tissue of the cow using technologies aimed at both ruminal protection and intestinal bioavailability.

ANION STRATEGY

Use a specific solution for the close-up/steaming up group (-20 days before calving), specifically developed and formulated by Granda Team (trade name DCADD), which contributes to achieving the anion strategy goals in a balanced and protracted way, thanks to a neutral effect on the final product palatability and therefore without interference on the Dry Matter ingestion capacity. Approximately 80% of Magnesium and Chlorine release occurs at abomasal/intestinal level with effective DCAD equal to -5140 meQ/kg tq allowing to obtain a targeted and effective action.

3. RUMEN HEALTH: ..BUT THE COW IS STILL A RUMINANT?? … FOR US YES !!!..

“Rumen health, in dairy cattle represents a truly crucial aspect and the balance of this variegated “condominium” should never be lost sight of in efficiency terms but also and above all for its intrinsic pathogenicity.”

Intrinsic pathogenicity induced when the rumen begins to become an important toxin release (LPS) source, as well as compounds that cannot be metabolized once they enter in the bloodstream, such as D-lactates.

LPS are endotoxins present in the Gram bacteria’s membrane, which dwell in the ruminal area even if in an absolutely lower quantity than Gram + bacteria. Their concentration increases in the subclinical rumen acidosis (SARA) presence conditions (Khafipour et al., 2011), inducing a corresponding LPS’s increase. These becomes significantly relevant when the acidosis becomes acute (Ametay et al., 2010, 2011).  LPS translocation predisposes the dairy cow to an acute systemic endotoxicosis due to the severity of LPS-induced toxemia (Emmanuel et al., 2007, 2008).

GRANDA TEAM’S RESPONSE WITH TRANSIZIONE 4.0 PROGRAM

Pay due attention to the rumen adaptation to the lactation ration, taking advantage from informations from the various studies carried out in this regard which show the importance of avoiding abrupt variations between the dry diet, close up/steaming up and post partum/lactation diet.

It is crucial to be able to reduce the LPS negative effects as well as their passage into the circulation, regardless of prepartum period management type and in consideration of the inevitable variations in the rumen ecosystem that characterize this phase. This objective can be achieved through specific LPS inactivator use (“LPS binder”). Trade name: TOX REM.

Recent analyses highlight extremely positive results about the high-producing cows physiometabolic balance following the TOX REM use in the post partum/lactation period as a specific and effective LPS inhibitor.

This nutritional solution activity also appears to be independent of the circulating endotoxins level, resulting effective even in the high concentrations presence.

4. DAIRY COWS FERTILITY: …MORE PROGESTERONE … LESS INFLAMMATION…PLEASE!!

“Progesterone is essential for the normal reproductive cycle; it inhibits estrus and controls follicle growth. But some high-producing dairy cows have not enough of it in circulation.” Penn State University.

“P4 circulating concentrations represent a balance between P4 production and P4’s metabolism; P4’s metabolism is primarily related to the blood flow’s amount to the liver due to the enzymes abundance in bovine liver that mediate P4 metabolism.” M.C.Wiltbank, A.H.Souza, P.D. Carvalho, A.P.Cunha, J.O.Giordano, P.M.Fricke, G.M.Baez and M.G. Diskin, 2014

INFLAMMATION and FERTILITY: a difficult relationship

• Reduction in the FSH and LH hormones production (less follicular development and ovulation absence)
• Luteolytic action of prostaglandins: blood progesterone reduction and embryonic mortality
• Uterine action: glandular epithelium reduction: > embryonic resorptions

2.GRANDA TEAM’S RESPONSE WITH TRANSIZIONE 4.0 PROGRAM

Restoring fertility within a dairy cows herd is not only the specific product’s research and use dedicated to it, but it effectively materialize in an application model that takes into consideration all the predisposing factors that have interfered with performance. GRANDA TEAM TRANSIZIONE 4.0 program is positioned in this way, as a systemic solution in programs and protocols support and in herd’s health and fertility support.

The cow’s ovarian cycle study has shown that the fertile follicle’s development depends on two metabolically correlated factors:

– the blood progesterone concentration

– the systemic inflammation reduction present in postpartum phase, especially in the summer (“heat stress”)

The fertility hormone (progesterone) concentration and the inflammatory stress quantification are, therefore, the two key factors to be analyzed in the fight against dairy cows hypofertility, especially in “stressogenic” factors precence that work in a negative sense in the new pregnancy establishment (heat stress, mycotoxins, etc…)

The dairy cows fertility management according to the Granda Team TRANSITION 4.0 protocol takes the form of the following steps:

1. ACCURATE HERD SCREENING DIRECTLY ON THE FARM

(Through the NUTRIL.HUB (made GRANDA TEAM) diagnostic/technological support)

2. BLOOD PROGESTERONE DETERMINATION

3. SISTEMIC INFLAMMATION DETERMINATION

4. ACCURACY AND PRECISION HEATS DETECTION

(Through the technological GRANDA TOOLS – COW MONITORING system support)

TO CONTRAST THE SYSTEMIC INFLAMMATION PRESENCE