INNOVATIVE TRANSITION PROTOCOL 4.0
Transition 4.0 was originally conceived as a working protocol aimed at introducing innovative analytical elements and solutions applicable to the transition period.
It is commonly accepted that the “pillars” of peripartum bovine health have been consolidated for some decades now, which means that technical research should be devoted to what still remains partly unknown:
- The occurrence of milk hypoproduction at week 4 for a considerable percentage of cows
- High incidence of “orphan diseases” in the immediate postpartum phase
NUTRIL.HUB is an operational tool created by GRANDA TEAM that transmits and analyzes technical data and metabolic readings to provide a 360° analysis on the incidence of peripartum pathologies and the negative consequences they induce in the lactation phase. With a particular focus on technical ideas made available by innovative and “cutting edge” research, products can be constantly reformulated to be more performant and technically up to date.
GRANDA TEAM’S TRANSITION 4.0 PROTOCOL FOCUSES ON THE FOLLOWING MACRO-TOPICS:
NMA: GRANDA TEAM'S ANSWER TO THE ISSUE OF KETOSIS
The nature of genetic selection in reproduction already inflicts a quasi-constant and persistent degree of lipid mobilization in the peripartum phase; therefore it is not possible to classify lipid mobilization as a veritable pathology, but rather a human induced metabolic necessity that we have to get used to managing.
WHAT IS THE CORRECT APPROACH to managing LIPID MOBILIZATION IN the TRANSITION period?
It is the adoption of an innovative and complete diagnostic-nutritional approach whose objective is to provide assistance to herds during the peripartum phase. This involves managing the flow of fats subject to mobilization and their subsequent metabolization allowing us to immediately ascertain exact levels of fats and how they will be metabolized. Even though NEFA and ketones are not strictly associated in diagnostic terms, they both synergistically target the same organ (hepatic cells in the liver). It is therefore necessary to stimulate and increase lipid mobilization and the oxidation of fats in the liver without neglecting nor underestimating the importance of each cofactor present in this metabolic pathway.
THE TRANSITION RESPONSE 4.0 (NMA NEB MANAGEMENT APPROACH OF GRANDA TEAM)
“Epat-ox transition” is a specific solution that represents a new approach to herds in Transition. This solution, researched and produced by Granda Team, can be applied to cows affected by NEB presenting high serum values of NEFA and BHBA. For use during the peripartum period, this product simultaneously achieves excellent production performance with an extremely low incidence of metabolic disease.
CONTROLLING HYPOCALCEMIA IS NO LONGER PROBLEMATIC
While acknowledging the importance of reducing the nutritional intake of potassium (K+) (Goff et al. 2004), it is nonetheless necessary to have a solution at hand that can be used whenever an excess intake of K+ is NOT solely manageable through fodder choice.
When managing the TRANSITION phase, nutritionists’ aim to restrict potassium intake during the close up stage. It is clear however, to all those managing dairy cowsheds, that the most suitable fodder choice to achieve this objective poses serious problems.
In order to correctly calculate DCAD as a ratio, it is necessary to know the total amount of K+ ingested by cows, and unfortunately the specialized software is unable to calculate it directly due to widely fluctuating levels of calcium present in fodder that are considered poor in K+ (e.g. corn silage or straw). These types of fodder are often included in the ratio with the aim of reducing the overall intake administered.
WHAT IS THE CORRECT APPROACH TO RESTRICTING POTASSIUM INTAKE DURING THE CLOSE UP PHASE AND REDUCING HYPOCALCEMIA?
- Not relying on potassium values emanating from traditional bibliographical sources
- Choosing the easiest to analyze substrate
- Selecting the most accurate method
- Cross-validating software data with that provided by urinary analyses
GRANDA TEAM’S RESPONSE USING THE TRANSITION 4.0 PROTOCOL
CAPTURING EXCESS POTASSIUM
K+ (as well as calcium) can be captured by supplying and administering the correct dosage of aluminosilicates.
To do this, you need a biological substrate indicator that can determine total potassium ingested and precisely determine much K+ needs to be captured; note that for this purpose the hematic value is irrelevant given that large quantities of minerals are excreted through the urine in order to maintain the narrow value ranges of homeostasis.
Granda Team’s CATION REM solution is able to render a portion of potassium non-absorbable.
In fact, testing has established that CATION REM, when inserted into CLOSE UP rations, 15 days prior to calving, allows potassium absorption levels equal to 50% of total intake present in the ration.
A balanced and protracted anion strategy using the DCADD solution which has both a neutral effect on palatability of the final product and doesn’t interfere with the ingestion capacity of Dry Matter.
RUMEN HEALTH: Is the cow still a ruminant? ..... For us YES!!!
Rumen health is crucial for dairy cattle. Finding the right balance of this varied “condominium” should never be far from sight in terms of efficiency and more importantly intrinsic pathogenicity.
It is therefore very important to dedicate attention to how rumen adapt to lactation ration by taking advantage of information emanating from various studies on this aspect which highlight the importance of avoiding sudden variations in dry, close-up and postpartum diet.
Therefore, the close-up formulation ration needs to follow specific prescriptions and targeted concentrations of energy, protein and minerals. Unfortunately, this is not always possible and non-compliance of this necessity is responsible for considerable problems.
The reasons as to why incorrect and unsuitable dietary rations are often administered can be manifold ranging from company size, absence of a prepartum group, lack of staff and even owners’ inattentiveness. The subsequent effect is the emergence of pathological conditions in the postpartum period; such conditions can reduce production levels and reproductive performance.
GRANDA TEAM’S RESPONSE WITH THE TRANSITION 4.0 PROTOCOL
It is fundamental to pay particular attention to LPS (Lipopolysaccharide Membranes) which are classed as metabolites at the top of xenobiotic toxicity chart (micrograms/ml) and produce proteins in the acute phase that then go on to provoke both acute and chronic effects.
It is therefore crucial to reduce the negative effects of LPS and prevent them from entering the circulatory system; this is important regardless of the prepartum management style adopted and the inevitable variations naturally taking place in a ruminal ecosystem during this phase. The TOX REM solution is the perfect product as it contains specific LPS deactivators that can achieve this objective.
In fact, TOX REM’s action works independently of circulating endotoxin levels making it effective even when concentration levels are high.
Granda Team’s TOX REM solution effectively achieves LPS inactivation at both local and systemic levels, thereby averting the harmful consequences of systemic inflammation (vasodilatation, fever, peripheral shock, loss of appetite). In addition, there is also the risk of impaired normal pre-stomach activity that is already put to the test in the postpartum period as a result of significant variations occurring in the ration.
More progesterone....less inflammation....please!!
In recent years scientific knowledge surrounding cattle hypo fertility issues have experienced a radical about turn.
Through studying cows’ ovarian cycles, it has been proven that the development of a fertile follicle is dependent on two metabolically related factors:
–the concentration of progesterone in the blood
–reducing systemic inflammation present in the postpartum phase, especially in summer (also known as “heat stress”).
The concentration of the fertility hormone (progesterone) and the quantification of inflammatory stress are, therefore, the two key factors to be analyzed in the fight against bovine hypo fertility, especially in the presence of “stressogenic” factors that negatively impact the formation of a new pregnancy (heat stress, mycotoxins, etc..
MORE PROGESTERONE… YES PLEASE!!
“Progesterone is essential to a normal reproductive cycle because it inhibits estrous and controls follicle growth. However, some high-yielding dairy cows have important circulatory progesterone deficiencies.”
Penn State University
“Circulating P4 concentrations represent the balance between P4 production and P4 metabolism; P4 metabolism is principally related to the quantity of blood flow to the liver due to an excess of enzymes that mediate P4 metabolism.”
M.C.Wiltbank, A.H.Souza, P.D. Carvalho, A.P.Cunha, J.O.Giordano, P.M.Fricke, G.M.Baez and M.G. Diskin, 2014
LESS INFLAMMATION… YES PLEASE!!
INFLAMMATION and FERTILITY: a difficult relationship
- Reduced production of FSH and LH hormones (less follicular development and absence of ovulation)
- Luteolytic action of prostaglandins: reduced blood progesterone levels and embryonic mortality
- Uterine action: glandular epithelium reduction: > embryonic reabsorption
Correlation between Hp in peripartum and subsequent ovulation
GRANDA TEAM ANSWER ON FERTILITY MANAGEMENT
LET’S KEEP IN TOUCH
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